葡萄籽提取物(GSE)主要是由聚合度为2～15的原花青素(89％)组成。作者研究了GSE抑制染色体损伤时的安全性和有效性。将非免疫球蛋白分泌的人B淋巴细胞WIL2-NS在含有不同浓度GSE的Hank’s平衡盐溶液(HBSS)中于37℃培养60min,然后用HBSS冲洗细胞以除去GSE,采用胞质分裂阻滞微核试验(CBMN)检测GSE诱导的染色体损伤。另将WIL2-NS细胞与 The grape seed extract (GSE) consists mainly of procyanidins with a degree of polymerization of 2-15 (89%). The authors studied the safety and efficacy of GSE in inhibiting chromosome damage. The non-immunoglobulin secreted human B lymphocytes WIL2-NS were cultured in Hank’s Balanced Salt Solution (HBSS) containing different concentrations of GSE at 37°C for 60 min, and then the cells were washed with HBSS to remove GSE, using cytokinesis micro The nuclear test (CBMN) detects GSE-induced chromosome damage. Another WIL2-NS cell