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目的了解宫颈癌患者治疗后人乳头状瘤病毒(HPV)感染的型别及分布情况。方法收集我院宫颈癌患者治疗后复诊的宫颈分泌物,采用导流杂交法检测宫颈上皮内HPV感染基因型。结果1216例检测标本中612例HPV阳性,感染率为50.39%;其中多重感染227例,占18.7%,单一感染385例,占31.7%单一亚型感染主要基因型为HPV16,其次为HPV18、HPV52、HPV31、HPV33等亚型。结论宫颈癌患者治疗后HPV感染率仍较高,因此进行HPV基因分型检测为临床医生判断治疗效果、基因预后奠定了分子学指标基础,对预测残留或复发有重要价值。同时,有利于患者随诊复检,给受检者最可靠的风险提示。
Objective To understand the type and distribution of human papillomavirus (HPV) infection in patients with cervical cancer. Methods Cervical secretions of patients with cervical cancer after treatment were collected and the genotypes of cervical intraepithelial HPV infection were detected by flow cytometry. Results A total of 612 cases of HPV were detected in 1216 samples with a prevalence of 50.39%. 227 cases were infected with multiple infections (18.7%), 385 cases were single infection (31.7%). The main genotype of single subtype was HPV16, followed by HPV18, HPV52 , HPV31, HPV33 and other subtypes. Conclusion The HPV infection rate of cervical cancer patients is still high after treatment. Therefore, the detection of HPV genotypes will lay a foundation for molecular judgment of clinicians’ judgment of therapeutic effect and prognosis of genes, and have important value in predicting residual or recurrence. At the same time, is conducive to patient follow-up re-examination, to the subjects the most reliable risk warning.