肝性脑病的病理生理变化迄今仍未阐明。脑代谢改变成为研究的焦点。其中氨基酸代谢紊乱可致脑神经递质的障碍。谷氨酸胺由星形胶质细胞合成，在肝性脑病的发病机制中具有作用。动物模型：同系Wistar雄性大鼠，组Ⅰ为假手术组，组Ⅱ为门腔分流术组；组Ⅲ为门腔分流术加脾内肝细 The pathophysiological changes of hepatic encephalopathy have not elucidated so far. Changes in brain metabolism has become the focus of research. Amino acid metabolism which can cause brain neurotransmitter disorders. Glutamine amines are synthesized by astrocytes and have a role in the pathogenesis of hepatic encephalopathy. Animal model: Wistar male rats of the same series, group I was sham operation group, group II was the group of gastrectomy; group III was gastrectomy combined with splenic liver function