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为探讨甘草甜素（ＧＬ） 和齐墩果酸（ＯＡ） 对大鼠镉中毒性肝损伤的防护作用及其作用机理，给大鼠腹腔注射ＣｄＣｌ２溶液（０－８ｍｇ Ｃｄ２＋／ｋｇ 体重），两组染镉大鼠分别同时皮下注射ＧＬ的生理盐水溶液（２０ｍｇ／ｋｇ，每周３ 次）和ＯＡ的吐温－ 生理盐水混悬液（６０ｍｇ／ｋｇ，每周５ 次），测定血清转氨酶、肝镉（Ｃｄ） 、金属硫蛋白（ＭＴ） 含量，检查肝组织病理形态学。结果显示：ＧＬ和ＯＡ延缓、降低了镉引起的血清转氨酶的升高，显著减轻了肝细胞肿胀、坏死及肝线粒体、滑面内质网病变的程度，明显减少了染镉初期镉在肝脏的蓄积，显著提高了肝内诱导的ＭＴ量。提示ＧＬ 和ＯＡ 对大鼠镉中毒性肝损伤有防护作用，此作用可能与其减少染镉初期镉在肝脏的蓄积及诱导ＭＴ或促进镉对ＭＴ 的诱导有关。
To investigate the protective effect of glycyrrhizin (GL) and oleanolic acid (OA) on cadmium-induced liver injury in rats and its mechanism of action, rats were intraperitoneally injected with CdCl2 solution (0-8 mg Cd2 + / kg body weight) Groups of cadmium-exposed rats were injected subcutaneously with GL saline (20mg / kg, 3 times a week) and Tween-saline suspension (60mg / kg, OA) Liver cadmium (Cd), metallothionein (MT) content, check liver histopathology. The results showed that GL and OA delayed the decrease of cadmium-induced serum aminotransferase, significantly reduced hepatocyte swelling and necrosis, and the degree of mitochondria and synovial endoplasmic reticulum lesions in liver, and significantly reduced the cadmium content in liver Accumulation, significantly increased the amount of liver induced MT. These results suggest that GL and OA may have a protective effect on cadmium-induced liver injury in rats, which may be related to the reduction of cadmium accumulation in the liver and the induction of MT or the induction of MT by cadmium.