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40年代就观察到尿毒症、胃癌患者出现红细胞形态异常。50年代注意到血栓形成与溶血性贫血的关系。1962年Brain、Dacie正式将转移癌患者出现畸形红细胞与溶血性贫血命名为MHA。并包含由于微血管病变引起的红细胞机械性损伤。其原发病除转移癌外,还有血栓性血小板减少性紫癜、恶性高血压、肾上腺皮质坏死、结节性动脉周围炎、急性肾炎、系统性红斑狼疮等。经动物实验证实,在急速的血流中有1μm以下的细丝或突起,就可引起红细胞破碎,并释放出溶血物质,于是形成恶性循环。日本于1966年首例报告,至1987年共158例。其中癌症患者137例(86.7%)。并以胃癌最多(117例),占全部病例的74.1%,癌症病例的85.4%,远高于其他
Uremia was observed in the 1940s and abnormal erythrocytes appeared in patients with gastric cancer. The 1950s noted the relationship between thrombosis and hemolytic anemia. In 1962, Brain, Dacie formally named patients with metastatic cancer deformity red blood cells and hemolytic anemia MHA. And contains mechanical damage to the red blood cells caused by microvascular disease. In addition to its primary disease in addition to metastatic cancer, but also thrombotic thrombocytopenic purpura, malignant hypertension, adrenal cortical necrosis, nodular periarteritis, acute nephritis, systemic lupus erythematosus. Animal experiments confirmed that in the rapid blood flow of 1μm below the filaments or protrusions, can cause red blood cell fragmentation, and the release of hemolysin material, so the formation of a vicious circle. Japan first report in 1966, up to 1987 a total of 158 cases. 137 cases of cancer patients (86.7%). And the most gastric cancer (117 cases), accounting for 74.1% of all cases, 85.4% of cancer cases, much higher than the other