单克隆丙种球蛋白病是一组异质性的疾病。一些是“恶性的”和非常急剧的,另一些是“良性的”和稳定的。良性单克隆丙种球蛋白病(BMG)或无决定意义的单克隆丙种球蛋白病(MGUS)胸腺嘧啶核苷标记指数(LI％)<1,进展性多发性骨髓瘤LI％则明显增高。BMG并发严重肾衰者很少。作者报告了1例单克隆丙种球蛋白病,由于k-轻链沉着于肾小球基底膜而引起肾衰。病历摘要:男性,33岁,因头痛、无力入院。入院时血清肌酐133μmol/l,肌酐清除率66ml/min。血 Monoclonal gammopathy is a heterogeneous group of diseases. Some are “vicious” and very sharp, others are “benign” and stable. Benign monoclonal gammopathy (BMG) or unidentified monoclonal gammopathy (MGUS) thymidine labeling index (LI%) <1, progressive multiple myeloma LI% was significantly higher. BMG complicated with severe renal failure are few. The authors report a case of monoclonal gammopathy that causes renal failure due to k-light chain deposition on the glomerular basement membrane. Medical record summary: Male, 33 years old, unable to hospital due to headache. Admission serum creatinine 133μmol / l, creatinine clearance 66ml / min. blood