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目的探讨肝硬化患者血清透明质酸含量与肝硬化病变程度及甲状腺激素水平的相关性。方法用放射免疫法测定了６９例不同程度的肝硬化患者血清透明质酸（ＨＡ）含量和甲状腺激素水平。结果随着临床肝硬化程度的加重，ＨＡ含量逐渐增高。而三碘甲状腺原氨酸（Ｔ３）、游离三碘甲状腺原氨酸（ＦＴ３），随ＨＡ的增高而下降，与ＨＡ含量呈显著负相关（ｒ＝－０．６２１和－０．４８４）；而甲状腺素（Ｔ４）、游离甲状腺素（ＦＴ４）可正常或下降，但在肝功能严重衰弱时也多呈低水平。结论肝硬化时，Ｔ３、ＦＴ３与ＨＡ呈显著负相关。联合检测ＨＡ与Ｔ３、ＦＴ３及Ｔ４、ＦＴ４浓度对估测肝硬化的严重程度及预后具有实用价值。
Objective To investigate the correlation between serum hyaluronic acid level and the degree of cirrhosis and thyroid hormone in cirrhotic patients. Methods Serum hyaluronic acid (HA) levels and thyroid hormone levels were measured in 69 patients with cirrhosis by radioimmunoassay. Results As the degree of clinical cirrhosis aggravated, HA content gradually increased. Triiodothyronine (T3) and free triiodothyronine (FT3) decreased with the increase of HA, but negatively correlated with HA (r = -0.621 and -0.484). Thyroxine (T4), free thyroxine (FT4) can be normal or decreased, but also in the serious decline of liver function mostly low level. Conclusions There was a significant negative correlation between T3, FT3 and HA during cirrhosis. Joint detection of HA and T3, FT3 and T4, FT4 concentrations have practical value in estimating the severity and prognosis of cirrhosis.