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生长因子具有旁分泌和/或内分泌作用。例如神经生长因子(NGF)、上皮生长因子(EGF),血小板由来生长因子(PDGF)、成纤维细胞生长因子(FGF)、类胰岛素生长因子Ⅰ(IGF-Ⅰ)和Ⅱ(IGF-Ⅱ);以及白细胞介素有旁分泌作用。生长因子可能还有内分泌作用。例如:IGF_s具有内分泌激素作用。IGF_s与蛋白结合,通过全身循环,而PDGF则在血小板内参与循环。所有生长因子是参与合成代谢的因素,它们的特异性是由细胞上的特异性受体决定的。然而,各种生长因子之间具有强烈的相互作用,例如:纤维母细胞增生就依赖于PDGF和IGF。
Growth factors have paracrine and / or endocrine effects. Such as nerve growth factor (NGF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), insulin-like growth factor I (IGF- As well as interleukins have paracrine effects. Growth factors may have endocrine effects. For example: IGF_s has an endocrine hormone effect. IGFs bind to proteins and circulate through the body, whereas PDGF participates in circulation within the platelets. All growth factors are involved in anabolic factors, and their specificity is determined by the specific receptors on the cell. However, there is a strong interaction between various growth factors, eg fibroblast proliferation is dependent on PDGF and IGF.