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目的探讨不同剂量阿托伐他汀钙片治疗高脂血症的临床疗效。方法选取2015年1—6月南宁市邕宁区人民医院收治的高脂血症患者76例,随机分为A组与B组,各38例。两组患者均给予常规治疗,在此基础上A组患者给予阿托伐他汀钙片10mg治疗,B组患者给予阿托伐他汀钙片20mg治疗,比较两组患者治疗前后血脂水平〔总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)水平〕、临床疗效,观察不良反应发生情况。结果治疗前两组患者TC、LDL-C、TG、HDL-C比较,差异无统计学意义(P>0.05);治疗后B组患者TC、LDL-C低于A组,差异有统计学意义(P<0.05);治疗后两组患者TG、HDL-C比较,差异无统计学意义(P>0.05)。B组治疗总有效率高于A组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论每天口服20mg阿托伐他汀钙片相比每天口服10mg治疗高脂血症的临床疗效确切,且不增加不良反应。
Objective To investigate the clinical efficacy of different doses of atorvastatin calcium tablets in the treatment of hyperlipidemia. Methods Sixty-six patients with hyperlipidemia who were treated in Nanning Suining People’s Hospital from January to June in 2015 were randomly divided into group A and group B, with 38 cases in each group. Both groups were given conventional treatment, on the basis of A group of patients given atorvastatin calcium 10mg treatment, B group of patients given atorvastatin calcium 20mg treatment, compared two groups before and after treatment of blood lipid levels 〔total cholesterol ( TC), LDL-C, TG and HDL-C levels were measured. The clinical efficacy and the incidence of adverse reactions were observed. Results There was no significant difference in TC, LDL-C, TG and HDL-C between the two groups before treatment (P> 0.05). After treatment, TC and LDL-C in group B were significantly lower than those in group A (P <0.05). There was no significant difference in TG and HDL-C between the two groups after treatment (P> 0.05). The total effective rate of group B was higher than that of group A, the difference was statistically significant (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Oral daily dose of 20mg atorvastatin calcium compared to oral administration of 10mg daily treatment of hyperlipidemia clinical efficacy and does not increase adverse reactions.