为了防止器官系统课程教学改革出现教学质量下滑，比较器官系统课程与学科课程体系教授病理生理学总论基础知识的教学效果。器官系统课程教学，课程内容整合符合“循序渐进”教学原则的2011和2012级学生成绩与课程体系教学的学生无差别；相反，课程内容衔接存在不足的2013和2014级，器官系统课程体系教学效果与学科课程体系教学效果相比呈现降低趋势或明显降低；补充课程知识衔接不足后，器官系统教学效果明显改善，好于学科课程体系。总结和反思器官系统课程教学改革的成效，再次验证基础医学教学同样必须遵循医学教育的内在规律，即“循序渐进”的教学原则。“,”In order to prevent the teaching reform of organ system curriculum from fall of teaching quality, the teaching effect of organ system curriculum and subject curriculum system in teaching the basic knowledge of pathophysiology was compared. In organ system curriculum teaching, there was no difference between the grades of students in Batch 2011 and Batch 2012 who conformed to the teaching principle of “gradual improvement” and those of the students taught with subject curriculum system. On the contrary, the students of Batch 2013 and Batch 2014 with insufficient curriculum content integration had a decreasing trend or a significant reduction in the teaching effect of organ system curriculum compared with that of subject curriculum system. After the supplementary for curriculum knowledge was made, the teaching effect of the organ system was significantly improved, which was better than that of the subject curriculum system. In conclusion, we have summarized and reflected on the effectiveness of the teaching reform of organ system curriculum, once again proved that basic medical teaching must also follow the inherent law of medical education, which is the teaching principle of “gradual improvement.”