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目的探讨盐酸利托君治疗早产胎膜早破的临床效果及其对新生儿结局的影响。方法收集2015年3月-2016年9月在海南医学院第二附属医院接受治疗的80例胎膜早破产妇为研究对象,采用随机抽取的方法将其分为观察组与对照组各40例,对照组采用硫酸镁治疗,观察组使用盐酸利托君进行治疗,对比两组患者治疗效果、新生儿Apgar评分、并发症等指标情况。结果观察组与对照组产妇宫缩抑制、孕龄延长时间及产后出血量存在显著差异(P<0.05),且观察组治疗总有效率(97.5%)明显比对照组(75.0%)高,两组数据比较差异有统计学意义(P<0.05)。观察组新生儿出生体重、Apgar评分与对照组比较差异有统计学意义(P<0.05),且观察组新生儿并发症发生率(5.0%)低于对照组(22.5%),组间数据对比差异有统计学意义(P<0.05)。结论早产胎膜早破者采用盐酸利托君治疗疗效显著,能有效减少产妇产后出血量,延长其孕龄时间,有利于降低新生儿并发症发生率,是一种值得在临床推广使用的方法。
Objective To investigate the clinical effect of ritodrine hydrochloride in the treatment of premature rupture of membranes and its effect on neonatal outcome. Methods Eighty pregnant women with premature rupture of membranes who were treated in the Second Affiliated Hospital of Hainan Medical College from March 2015 to September 2016 were selected as study subjects and randomly divided into observation group and control group with 40 cases . The control group was treated with magnesium sulfate. The observation group was treated with Rituxan Hydrochloride. The therapeutic effect, neonatal Apgar score and complication were compared between the two groups. Results There was significant difference between the observation group and the control group in maternal tightening, prolonged gestational age and postpartum hemorrhage (P <0.05), and the total effective rate (97.5%) in the observation group was significantly higher than that in the control group (75.0%), There was significant difference between groups (P <0.05). The birth weight and Apgar score in the observation group were significantly different from those in the control group (P <0.05), and the incidence of neonatal complications in the observation group (5.0%) was lower than that in the control group (22.5%). The difference was statistically significant (P <0.05). Conclusion Preterm premature rupture of membranes with rituximab treatment of patients with significant effect, can effectively reduce the amount of maternal postpartum hemorrhage, prolong their gestational age, is conducive to reduce the incidence of neonatal complications, is a method worthy of clinical promotion .