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为预测枸橼酸克罗米酚(CC)在黄体机能不全治疗中的恰当容量,对117例患者用放射免疫方法测定其血清孕酮(P)和催乳素(PRL)浓度,评价疗效。取自病人的三次混合晨血清标本中PRL值高于700mU/l定为高PRL血症。每一月经周期黄体期每2天测量一次血清P水平,至少5次,选择3个最高P水平的平均值代表黄体功能。连续2个周期黄体期P最大值在3～10ng/ml之间者定为黄体机能不全。对P最高水平在10～15ng/ml之间并有临床不能解释的不孕症患者,当3次P最大值平均在10ng/ml以下时也列入本组。
In order to predict the appropriate capacity of clomiphene citrate (CC) in the treatment of corpus luteum, 117 patients were evaluated for their serum progesterone (P) and prolactin (PRL) levels by radioimmunoassay. PRL values higher than 700 mU / l in triple mixed morning serum samples from patients were assigned to high PRL hyperlipidemia. Serum P levels were measured every 2 days in the luteal phase of each menstrual cycle, at least 5 times, and the average of the 3 highest P levels was chosen to represent the corpus luteum function. L consecutive two cycles of luteal phase P maximum between 3 ~ 10ng / ml was defined as luteal insufficiency. In patients with infertility whose highest P level is between 10 and 15 ng / ml and which can not be explained clinically, this group is also included when the average of 3 times P max is below 10 ng / ml.