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目的探讨臭氧对急性脑梗死患者血清谷氨酸浓度的影响。方法选取2014年1月至2015年5月郑州大学附属郑州市中心医院神经内科收治的74例急性脑梗死患者作为研究对象,根据入院顺序采用随机队列插入法将其分为对照组和观察组,各37例。对照组患者给予常规对症治疗,观察组患者在对照组基础上采用臭氧进行治疗,比较两组患者的神经功能缺损情况、血清谷氨酸水平及临床疗效。结果治疗第1天,两组患者的NIHSS评分、血清谷氨酸水平差异均无统计学意义(均P>0.05);第7天、14天,观察组患者的NIHSS评分均明显低于对照组,差异均有统计学意义(均P<0.05);第14天观察组患者的血清谷氨酸水平明显低于第1天、第7天,且第7天、第14天观察组明显低于对照组,第7天对照组患者的血清谷氨酸水平高于第1天、第14天、同期观察组,差异均有统计学意义(均P<0.05);第7天观察组神经功能缺损评分变化幅度(y)与血清谷氨酸水平变化值(x)存在相关性;观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论臭氧治疗急性脑梗死有助于增进疗效,血清谷氨酸浓度可作为疗效预测指标;臭氧治疗早期血清谷氨酸浓度与神经功能恢复成正比。
Objective To investigate the effect of ozone on serum glutamate concentration in patients with acute cerebral infarction. Methods Seventy-four patients with acute cerebral infarction admitted to Department of Neurology, Zhengzhou Central Hospital from January 2014 to May 2015 were enrolled in this study. Patients were divided into control group and observation group according to admission sequence, 37 cases each. The patients in the control group were given conventional symptomatic treatment. The patients in the observation group were treated with ozone on the basis of the control group. The neurological deficit, serum glutamate level and clinical efficacy were compared between the two groups. Results On the first day of treatment, there was no significant difference in NIHSS score and serum glutamate level between the two groups (all P> 0.05). On the 7th and 14th days, the NIHSS scores of the observation group were significantly lower than those of the control group (All P <0.05). On the 14th day, the level of serum glutamate in the observation group was significantly lower than that on the first day and the seventh day, and the observation group was significantly lower than the observation group on the seventh day and the fourteenth day In the control group, the level of serum glutamate in the control group on the 7th day was higher than that on the 1st, 14th and the same period in the observation group (all P <0.05); on the 7th day, the neurological deficit There was a correlation between the change of the score (y) and the change of the serum glutamate level (x). The total effective rate of the treatment group was significantly higher than that of the control group (P <0.05). Conclusion Ozone treatment of acute cerebral infarction can help to improve the efficacy of serum glutamic acid concentration can be used as a predictor of efficacy; early serum ozone concentration of glutamate and nerve function recovery is proportional to.