Klockboff等采用甘油脱水使美尼尔氏病患者血浆渗透压增加,听力一过性改善,但增加血浆渗透压对正常人听阈无影响。Angelborg等使头验动物血浆渗透压增加,可引起内淋巴流量改变。但血液和脑脊液可凭借血脑屏障维持不同的渗透压,血液与内淋巴间也有类似情况。作者以动物实验观察血浆渗透压降低是否可增加内淋巴流量而导致内淋巴水肿,后者据耳蜗微音器电位及N_1阈值评价。取幼豚鼠25只,4只测CM余测N_1阈。19只经耳郭后径路 Klockboff and other glycerol dehydration so that patients with Meniere’s disease increased plasma osmolality, transient hearing improvement, but increased plasma osmolality had no effect on the normal hearing threshold. Angelborg et al increased the plasma osmolality of the head animal and caused changes in the endolymphatic flow. However, the blood and cerebrospinal fluid with the blood-brain barrier can maintain different osmotic pressure, blood and endolymphatic also have a similar situation. The authors observed in animals whether the decrease in plasma osmolality could increase the endolymphatic flow and lead to endolymphatic edema, the latter based on the cochlear microphones potential and N_1 threshold evaluation. Twenty-five young guinea pigs were taken, and four of them were tested for residual N_1 threshold. 19 only after the ear Guo path