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目的:观察国产吉西他滨(GEM)联合奈达铂(NDP)组成的GN方案治疗晚期非小细胞肺癌(NSCLC)的疗效和安全性。方法:52例NSCLC患者采用GN方案:GEM1 000mg/m2,第1、8天静脉滴注,NDP 80mg/m2,第2天静脉滴注,21天为1周期。结果:全组52例中,完全缓解3例(5.77%),部分缓解17例(32.69%),稳定23例(44.23%),进展9例(17.31%),有效率为38.46%,疾病控制率82.69%。主要毒副反应为骨髓抑制,经对症处理后可以缓解,无治疗相关死亡。结论:国产吉西他滨联合奈达铂治疗晚期NSCLC疗效较好,毒副反应轻。
Objective: To observe the efficacy and safety of domestic gemcitabine (GEM) combined with nedaplatin (NDP) GN regimen in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: Fifty-two patients with NSCLC underwent GN regimen: GEM1 000 mg / m2, intravenous drip on day 1,8, NDP 80 mg / m2, intravenous drip on the second day, and one cycle on the 21st day. Results: Among the 52 cases, complete remission was achieved in 3 cases (5.77%), partial remission in 17 cases (32.69%), stable in 23 cases (44.23%), progression in 9 cases (17.31%), effective rate was 38.46% Rate of 82.69%. The main side effects of bone marrow suppression, symptomatic treatment can be alleviated, no treatment-related deaths. Conclusion: The domestic gemcitabine combined with nedaplatin in the treatment of advanced NSCLC has good curative effect and light toxicity.