AT—1420即甲基苯丙氨酸氮芥,它对大小鼠移植性肿瘤具有明显的抗瘤作用,疗效与消瘤芥(AT—1258)相似,而用量较小。 在大鼠急性和狗的亚急性毒性试验说明,AT—1420有明显抑制骨髓作用和胃肠道毒性,但对其他器官无明显的毒性作用。对大鼠连续用药2个月亦未见明显的积蓄性毒性。为此表明对于疗程较长且反复用药的抗肿瘤治疗是较理想的药物。 AT-1420 is methyl phenylalanine mustard, which has obvious anti-tumor effect on transplanted tumors in large mice. The efficacy is similar to that of tumor elimination (AT-1258), but the amount is small. The acute and dog subacute toxicity tests in rats showed that AT-1420 had significant inhibition of bone marrow and gastrointestinal toxicity, but no significant toxic effects on other organs. There was no significant accumulation of toxicities after continuous administration of the rats for 2 months. This shows that for longer course of treatment and repeated anti-cancer treatment is an ideal drug.