目的:探讨DLL4和VEGF在膀胱移行细胞癌(BTCC)中的表达和意义。方法:采用免疫组化(S-P法)结合计算机图像定量分析技术检测50例BTCC组织和10例正常膀胱组织中DLL4和VEGF的表达情况,测定平均光密度(MOD)。结果:BTCC组中DLL4和VEGF阳性表达率分别为90%(45/50)和64%(32/50),对照组膀胱组织中DLL4无表达,1例VEGF阳性表达,DLL4与VEGF在BTCC组织和正常对照组表达均有统计学意义(P<0.05);BTCC组织中DLL4表达与组织学病理分级呈负相关,VEGF表达与组织学病理分级呈正相关(P<0.05);BTCC组织中DLL4表达与临床分期呈负相关,VEGF表达与临床分期呈正相关(P<0.05);初发性和复发性BTCC组织中DLL4表达量的差异与VEGF表达量的差异均有统计学意义;BTCC组织中DLL4和VEGF之间的表达呈负相关(r=-0.604,P=0.035)。结论:DLL4和VEGF表达与BTCC的分期、分级及肿瘤的预后有关;综合DLL4和VEGF在BTCC组织中的表达情况判断肿瘤预后,从而可以在早期选择更优化的治疗方案,并且靶定DLL4可能成为一个新的抗血管生成的治疗方法。 Objective: To investigate the expression and significance of DLL4 and VEGF in bladder transitional cell carcinoma (BTCC). Methods: The expressions of DLL4 and VEGF in 50 BTCC tissues and 10 normal bladder tissues were detected by immunohistochemistry (S-P) combined with computer image quantitative analysis. The mean optical density (MOD) was measured. Results: The positive rates of DLL4 and VEGF in BTCC group were 90% (45/50) and 64% (32/50) respectively, while in the control group, no expression of DLL4 and VEGF was found in 1 case of BTCC, (P <0.05). The expression of DLL4 in BTCC was negatively correlated with histological grade, and the expression of VEGF was positively correlated with histological grade (P <0.05). The expression of DLL4 in BTCC There was a positive correlation between VEGF expression and clinical stage (P <0.05). There was significant difference between the expression of DLL4 and the expression of VEGF in primary and recurrent BTCC tissues. The expression of DLL4 And VEGF expression was negatively correlated (r = -0.604, P = 0.035). Conclusion: The expression of DLL4 and VEGF is related to the stage and grade of BTCC and the prognosis of the tumor. The expression of DLL4 and VEGF in BTCC can be used to judge the prognosis of the tumor, so that a more optimized treatment plan can be selected in the early stage and target DLL4 may become A new anti-angiogenic treatment.