目的了解新疆哈萨克族高尿酸血症患者的血脂水平,分析哈萨克族高尿酸血症与脂代谢之间的关系。方法在新疆伊犁哈萨克族居民集中的地区随机抽取256例作为研究对象,其中高尿酸血组128例,对照组128人,分别检测血尿酸(SUA)及血脂相关生化指标。结果生化指标中除总胆固醇TC、载脂蛋白-A1(Apo-A1)外,高尿酸组血尿酸SUA(469.31±87.38)μmol/L、尿素氮BUN(6.10±2.45)mmol/L、肌酐SCr(88.34±20.39)μmol/L、甘油三酯TG(1.66±1.24)mmol/L、低密度脂蛋白胆固醇LDL-C(2.72±1.13)mmol/L、载脂蛋-B(Apo-B)为(0.91±0.27)g/L、空腹血糖GLU(6.12±2.52)mmol/L,均高于对照组(P<0.05);高密度脂蛋白胆固醇HDL-C(1.49±0.82)mmol/L、Apo-A1/Apo-B(1.36±0.42)低于对照组(P<0.01).高尿酸组SUA男性(509.21±91.73)μmol/L,女性(424.09±54.46)μmol/L;对照组SUA男性(248.89±75.37)μmol/L,女性(199.49±54.30)μmol/L,差异均有统计学意义(P<0.01);各年龄段均存在不同程度的脂代谢紊乱(除了≤30岁年龄段),以31～40岁年龄段脂代谢紊乱最为明显;相关性分析中血尿酸与年龄、TC、TG、BUN、SCr、LDL-C、Apo-B呈正相关,与HDL-C、Apo-A1/Apo-B呈负相关;多元回归分析结果表明,性别、HDL-C、BUN、TC、Apo-A1、Apo-A1/Apo-B是影响血尿酸的独立危险因素。结论哈萨克族高尿酸血症患者的血脂水平均高于非高尿酸血症者;其尿酸水平的升高与脂代谢紊乱的发生密切相关;建议预防和治疗哈萨克族高尿酸血症时,应注意控制血脂水平的变化,降低血脂有助于治疗高尿酸血症。 Objective To understand the blood lipid levels of Kazakh patients with hyperuricemia in Xinjiang and to analyze the relationship between Kazakh hyperuricemia and lipid metabolism. Methods A total of 256 randomly selected subjects were enrolled in this study. 128 cases of hyperuricemia and 128 cases of control group were included in the study. Serum uric acid (SUA) and blood lipid-related biochemical parameters were measured. Results The levels of SUA (469.31 ± 87.38) μmol / L, BUN (6.10 ± 2.45) mmol / L, creatinine SCr (88.34 ± 20.39) μmol / L, triglyceride TG (1.66 ± 1.24) mmol / L, low density lipoprotein cholesterol LDL-C (2.72 ± 1.13) mmol / L and Apo-B (0.91 ± 0.27) g / L and fasting glucose (GLU) (6.12 ± 2.52 mmol / L, all higher than those in the control group (P <0.05; HDL-C -A1 / Apo-B (1.36 ± 0.42) were lower than those in the control group (P0.01) .High uric acid group SUA male (509.21 ± 91.73) μmol / L and female (424.09 ± 54.46) μmol / 248.89 ± 75.37) μmol / L, and female (199.49 ± 54.30) μmol / L, all of which were statistically significant (P <0.01). There were different degrees of dyslipidemia (except ≤30 years old) Serum uric acid was positively correlated with age, TC, TG, BUN, SCr, LDL-C, Apo-B in HDL-C, Apo-A1 / Apo B were negatively correlated. Multiple regression analysis showed that sex, HDL-C, BUN, TC, Apo-A1 and Apo-A1 / Apo- Independent risk factors. Conclusions The level of serum lipids in Kazakh patients with hyperuricemia is higher than those without hyperuricemia. The increase of uric acid levels is closely related to the disorder of lipid metabolism. It is suggested that when preventing and treating Kazakh hyperuricemia, Control of blood lipid levels, reduce blood lipids help to treat hyperuricemia.