目的 :观察国产粒细胞集落刺激因子瑞血新 (rhG -CSF)对急性白血病化疗后所致粒细胞减少的治疗效果和毒副反应。方法 :采用自身前后对照 ,对急性白血病化疗后外周血粒细胞 ,其绝对值 <0 5× 10 9/L伴发热的患者 ,给该药 15 0ug/天 ,皮下注射 ,至外周血粒细胞连续 2次 >1 5× 10 9/L停药。结果 :用药后外周血粒细胞恢复时间及发热持续时间较对照组明显缩短 (粒细胞恢复时间分别为 9 4d和 2 2 7d ,发热持续时间分别为 7 5d和 13 4d) ,所有患者均耐受全部化疗过程。结论 :rhG -CSF有效促进化疗后外周血粒细胞的恢复 ,有利于及时控制感染 ,价格低廉 ,疗效可靠 ,副作用小 Objective: To observe the therapeutic effect and toxicity of domestic granulocyte-colony stimulating factor (HSG-CSF) on neutropenia caused by acute leukemia after chemotherapy. Methods: The peripheral blood neutrophils of acute leukemia after chemotherapy were treated with their own absolute value of <0 5 × 10 9 / L with fever. The patients were injected subcutaneously with 150 μg / 2 times> 1 5 × 10 9 / L withdrawal. Results: The recovery time of peripheral blood neutrophils and the duration of fever were significantly shorter than those of the control group (the recovery time of granulocytes was 9 4 days and 227 days respectively, the duration of fever was 75 days and 134 days respectively), and all the patients were tolerant All chemotherapy. Conclusion: rhG-CSF can effectively promote the recovery of peripheral blood neutrophils after chemotherapy, which is beneficial to timely control of infection, low price, reliable curative effect and small side effect