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目的： 探讨灌注－延迟显像方法在肝脏ＶＸ２ 肿瘤声学造影中的增强效果及变化规律。方法： ９ 只患有ＶＸ２ 肝肿瘤的新西兰白兔经外周静脉注射氟碳声学造影剂， 按常规连续显像方法和灌注－延迟显像方法分别用高频二次谐波显像观察肿瘤造影效果。结果： 灌注－延迟显像产生的视觉肿瘤显影评分显著高于常规二次谐波显像 （Ｐ＜０．０１）， 灌注－延迟显像和常规显像的肿瘤显影视频密度值分别为１１８．３８±１８．４１ 和８７．８３±１７．０３ （Ｐ＜ ０．０１）。常规显像方法和灌注－延迟显像方法在对于 ５－１０ｍ ｍ 肿瘤结节的超声检出率分别为 ６３．６％ 和９０．９％ 。结论： 灌注－延迟显像方法在确保观察到肿瘤血管早期增强现象的同时， 可以显著提高ＶＸ２ 肿瘤声学造影的影像对比度和诊断敏感性。
Objective: To investigate the enhancement effect and change rule of perfusion-delayed imaging in the liver VX2 tumor angiography. Methods: Nine New Zealand white rabbits with VX2 liver tumor were injected with fluorocarbon contrast agent through peripheral vein. The imaging results of tumor were observed by high frequency second harmonic imaging according to routine continuous imaging and perfusion - delayed imaging . Results: The perfusion - delayed imaging showed significantly higher visual tumor imaging scores than conventional second harmonic imaging (P <0.01). The perfusion - delayed imaging and conventional imaging of tumor imaging were 118. 38 ± 18.41 and 87.83 ± 17.03 (P <0.01). Conventional imaging methods and perfusion-delayed imaging methods were 63.6% and 90.9%, respectively, for ultrasound-specific nodules of 5-10 m in diameter. CONCLUSION: Perfusion-delayed imaging can significantly improve the contrast and diagnostic sensitivity of VX2 tumor acoustic contrast imaging while ensuring early enhancement of tumor blood vessels.