论文部分内容阅读
目的分析莫西沙星联合抗结核药物治疗难治性结核性膜炎的临床疗效。方法 56例难治性结核性脑膜炎患者,随机分为联合组和对照组,每组28例。对照组采用抗结核药物进行治疗,联合组在对照组的基础上加用莫西沙星进行治疗。比较两组治疗前、治疗后6个月脑脊液指标以及发热时间、昏迷时间和住院时间。结果与对照组比较,联合组治疗后脑脊液中氯化物、葡萄糖含量均显著增高,压力、蛋白质以及白细胞计数均显著降低(P<0.05);联合组发热时间、昏迷时间较对照组明显降低(P<0.05);联合组住院时间为(28.16±5.42)d,低于对照组的(34.09±5.77)d(P<0.05)。结论莫西沙星联合抗结核药物治疗难治性结核性脑膜炎可以明显的改善脑脊液指标,较快的减轻患者临床症状,缩短住院时间,具有推广的临床价值。
Objective To analyze the clinical efficacy of moxifloxacin in combination with anti-TB drugs in the treatment of refractory tuberculous meningitis. Methods 56 patients with refractory tuberculous meningitis were randomly divided into combined group and control group, 28 cases in each group. The control group was treated with anti-TB drugs, and the combination group was treated with moxifloxacin on the basis of the control group. Before treatment, 6 months after treatment, cerebrospinal fluid index, fever time, coma time and hospital stay were compared. Results Compared with the control group, the contents of chloride and glucose in cerebrospinal fluid were significantly increased and the pressure, protein and leukocyte count were significantly decreased in the combination group (P <0.05). The fever time and coma time in the combination group were significantly lower than those in the control group (P <0.05). The length of stay in the combined group was (28.16 ± 5.42) d, which was lower than that in the control group (34.09 ± 5.77) d (P <0.05). Conclusion Combination of moxifloxacin and anti-tuberculosis drugs in the treatment of refractory tuberculous meningitis can significantly improve the cerebrospinal fluid markers, reduce clinical symptoms and shorten the hospitalization time, and has the clinical value of promotion.