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目的:研究象皮生肌膏对压疮缺血再灌注损伤大鼠新生肉芽组织中纤维结合蛋白含量的影响。方法:在SD雄性大鼠大腿部建立压疮体表皮肤缺损创面模型,随机分为实验组、阳性对照组和空白对照组,每组10只,实验组外用象皮生肌膏,阳性对照组使用水胶体敷料,空白对照组外敷生理盐水纱布。治疗后的第7天、第14天、第21天、第28天取创伤组织制成组织切片,观察其病理学变化。观察外用象皮生肌膏对大鼠溃疡愈合时间及愈合率的影响,比较3组大鼠肉芽组织中纤维结合蛋(fibronectin,FN)含量。结果:3组溃疡创面愈合率及愈合时间比较,差异均有统计学意义(P<0.05)。实验组大鼠新生肉芽组织中纤维结合蛋白含量与对照组比较,差异有统计学意义(P<0.05)。结论:象皮生肌膏能提高压疮缺血再灌注损伤大鼠新生肉芽组织中纤维结合蛋白含量,对压疮伤口愈合有促进作用。
OBJECTIVE: To study the effect of elephant skin Shengji Ointment on the content of fibronectin in granulation tissue of newborn rats with pressure ulcer ischemia-reperfusion injury. Methods: A wound model of pressure ulcer skin defect was established in the thigh of SD male rats and randomly divided into experimental group, positive control group and blank control group, with 10 rats in each group. Group using hydrocolloid dressing, blank control group topical saline gauze. On the 7th day, the 14th day, the 21st day and the 28th day after the treatment, wound tissues were obtained and histopathological changes were observed. To observe the effect of elephant exfoliating plaster on ulcer healing time and healing rate in rats, and to compare the content of fibronectin (FN) in the granulation tissue of the three groups. Results: The healing rate and healing time of ulcer wounds in three groups were statistically significant (P <0.05). Compared with the control group, the content of fibronectin in fresh granulation tissue in experimental group was significantly different (P <0.05). Conclusion: Xiangpi Shengji Ointment can improve the content of fibronectin in the granulation tissue of newborn rats with pressure ulcer ischemia-reperfusion injury and promote the wound healing of pressure ulcer.