Purpose: To compare a new ophthalmic viscoelastic device (OVD) Healon 5 with twoother kinds of OVDs commonly used in China during phacoemulsification and intraocularlens (IOL) implantation in terms of removal time, intraocular pressure, ceal andanterior chamber response.Methods: This prospective randomized study, in which patients and observers aremasked, comprises niety eyes. They were randomly divided into 3 groups with differentOVDs. Healon 5 (sodium hyaluronate 5 000 2.3 % ) was compared with Healon GV(sodium hyaluronate 7 000 1.4 % ) and Iviz (sodium hyaluronate 1.0 % ) . Thesurgeries were performed with temporal ceal incision, phacoemulsification in situ andfoldable lens intracapsular implantation. The characteristic and the removal time of theviscoelastic material as well as the postoperative IOP, ceal reaction and anteriorchamber reactions of the eyes were observed preoperatively and 24 hrs postoperatively.Exclusion criteria were glaucoma, a preoperative dilated pupil diameter smaller than 5.0mm, proliferative diabetic retinopathy, significant ceal pathology or a history ofuveitis.Results: The removal time was 47.42 ± 13.09 seconds in Healon 5, 16. 50 ± 5.45 inHealon GV and 15.83±7.40 in Iviz. The removal time of Healon 5 group wassignificantly longer than that of the other groups ( P =0. 000) . There is no significantIOP change 24 hours postoperatively and the difference of intraocular pressure amongthree groups was not significant ( P ＞ 0.05). Healon 5 group had the slightest cealand anterior chamber response, followed by Healon GV and Iviz.Conclusion: Although takes longer time to remove, Healon 5 is an ideal viscoelasticmaterial for its superior space maintenance capacity and high dispersity which providessuperior protection of endothelial cells compared to Healon GV and Iviz.