为探讨局部振动对血浆内皮素、一氧化氮浓度的影响,及其与振动性血管损伤之间的关系,对不同接振时间、不同接振强度的家兔测定了血浆内皮素和一氧化氮浓度。结果表明,随接振时间的延长和接振剂量的增大,实验组血浆内皮素浓度有升高的趋势,血浆一氧化氮浓度有降低趋势。认为局部振动导致血浆内皮素浓度的增高以及一氧化氮浓度的下降,可能是振动性血管损伤的发病机理之一 To investigate the effect of local vibration on plasma endothelin and nitric oxide concentrations and their relationship with vasoconstrictive vascular injury, the levels of plasma endothelin and nitric oxide concentration. The results showed that the plasma endothelin concentration in the experimental group tended to increase with the increase of the vibration-absorbing time and the dose of vibration-induced vibration, and the plasma nitric oxide concentration tended to decrease. It is considered that local vibration leads to the increase of plasma endothelin concentration and the decrease of nitric oxide concentration, which may be one of the pathogenesis of VIB