Ko等人的研究表明,5.3%的未感染的婴儿对3剂或4剂系列的初次乙肝疫苗没有应答,疫苗无应答的发生率与接种后血清测试(PVST)的时间间隔呈负相关,1~2个月是2.0%,15~16个月是2 1.6%。之前已经有报道完成全程疫苗接种者的抗体阳性率 Ko et al.’s study showed that 5.3% of uninfected infants did not respond to a 3 or 4 dose series of primary hepatitis B vaccine. The incidence of vaccine non-response was inversely related to the time interval after vaccination serum test (PVST), 1 2.0% for ~ 2 months and 21.6% for 15 ~ 16 months. There have been reports before the completion of the entire vaccination antibody positive rate