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肝是众多恶性肿瘤血道转移的最常见靶器官,肝转移又和脑转移、骨转移以及肺转移等关系密切,目前认为,它是脑转移之外的生存率最低的转移癌。近来研究表明,紧密连接蛋白claudins是转移癌发生过程中的主要调控分子,也是调控肿瘤生物学行为的重要靶点。乳腺癌肝转移过程中起重要作用的是claudin-2、claudin-4和claudin-12,其分别在增强乳腺癌细胞与肝细胞的黏附能力、血管生成拟态及IL-18的相互调节中发挥重要作用。
The liver is the most common target organ for metastasis of many malignant tumors. Hepatic metastasis is closely related to brain metastasis, bone metastasis, and lung metastasis. Currently, it is considered to be the metastatic cancer with the lowest survival rate except brain metastasis. Recent studies have shown that Claudins, a tight junction protein, is a major regulator in metastatic carcinogenesis and an important target for the regulation of tumor biological behavior. The role of claudin-2, claudin-4, and claudin-12 in the process of liver metastasis from breast cancer plays an important role in enhancing the adhesion of breast cancer cells and hepatocytes, the mimicry of angiogenesis, and the mutual regulation of IL-18, respectively. effect.