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70年代β-内啡肽(β-EP)只被认为是一种内生性疼痛阻滞剂。随着β-EP在神经系统以外其他器官中的发现,对其生理作用有了新的认识。本文综述β-EP在女性生殖内分泌中的作用,β-EP通过的多巴胺能机制调节LHRH的活性,从而参与垂体LH分泌的调节。卵泡粒层细胞、黄体细胞对β-EP抗血清呈阳性反应,推测β-EP与卵泡成熟有关。β-EP在月经周期中呈周期性变化,很可能说明它参与月经周期的调节。
The 70s β-endorphin (β-EP) is only considered as an endogenous pain blocker. With the discovery of β-EP in other organs outside the nervous system, a new understanding of its physiological role has been made. This review summarizes the role of β-EP in female reproductive endocrine. Β-EP regulates the activity of LHRH through the dopaminergic mechanism and thus participates in the regulation of LH secretion. Follicular granulosa cells, corpus luteum cells positive for β-EP antiserum, speculated that β-EP and follicular maturation. Beta-EP periodically changes in the menstrual cycle, it is likely that it is involved in the regulation of the menstrual cycle.