近年来 ,雌激素在治疗骨质疏松症方面的用途正越来越受到人们的关注。雌甾— 3—氯乙基醚是合成骨定向雌激素的重要中间体 [1,2 ] ,文献 [3] 报道其合成方法操作烦琐、冗长 ,收率低 ,重复性差。本文采用了新的合成路线 ,用 1 ,2—二氯乙烷既作溶剂又作烃化剂 ,在四正丁基溴化铵 In recent years, the use of estrogen in the treatment of osteoporosis is attracting more and more attention. Estrogen-3-chloroethyl ether is an important intermediate for the synthesis of bone-oriented estrogen [1,2]. The literature [3] reported that its synthesis method is cumbersome, lengthy, low yield and poor reproducibility. In this paper, a new synthetic route, using 1,2-dichloroethane both as a solvent and as a hydrocarbon agent, tetra-n-butylammonium bromide