真菌性脑膜炎虽不多见,但因缺乏有效的治疗方法,常可致死。目前该病诊断主要依靠真菌培养。新型隐球菌和厌酷球孢子菌的单次脑脊液(CSF)阳性培养结果就有临床意义,然而缺乏相应的临床资料则很难解释念珠菌或腐生霉菌单次阳性结果。本文回顾性研究德克萨斯儿童医院6年中收治的病人CSF所分离到的真菌,以探索其临床意义,以及如何区别系感染菌抑或污染菌。 Although fungal meningitis is rare, but due to the lack of effective treatment, often lethal. The diagnosis of the disease depends mainly on fungal culture. Single CSF positive cultures of Cryptococcus neoformans and Cococci are clinically relevant, however, the lack of appropriate clinical data makes it difficult to explain single positive results for Candida or Somnophorus. This study retrospectively studied the fungal isolated from CSF patients admitted to Texas Children’s Hospital for 6 years to explore its clinical significance and how to differentiate between infectious and bacterial contaminants.