目的:探讨颈动脉内-中膜厚度对冠状动脉病变的预测价值。方法:根据冠状动脉造影结果,将183例行冠状动脉造影的患者分为3组:正常组59例为冠状动脉造影阴性;A组54例冠状动脉狭窄率<50%;B组70例冠状动脉狭窄率≥50%。根据冠状动脉病变数量将124例冠状动脉狭窄的患者进一步分为单支病变组40例,双支病变组38例和多支病变组46例。所有患者行颈动脉超声检查,测量颈动脉内-中膜厚度。结果:A组、B组的颈动脉内-中膜厚度和冠脉积分(Gensini评分)均明显高于正常对照组,且B组颈动脉内-中膜厚度和Gensini评分均较A组明显增加,差异均有统计学意义(P<0.05)。随着冠状动脉狭窄程度的加重,颈动脉内-中膜厚度和Gensini评分逐渐增加。多支病变组、双支病变组IMT值和Gensini评分均显著高于单支病变组(P<0.05),而双支病变组与多支病变组比较差异均无统计学意义(P>0.05)。颈动脉IMT厚度与冠状动脉病变数量相关性不大,与Gensini评分呈显著性正相关(P<0.01)。结论:颈动脉内-中膜厚度能较好地预测冠状动脉病变程度,但不能预测冠状动脉病变范围。 Objective: To investigate the predictive value of carotid artery intima - media thickness on coronary artery disease. Methods: According to the results of coronary angiography, 183 patients undergoing coronary angiography were divided into 3 groups: 59 patients in normal group had negative coronary angiography; 54 patients in group A had less than 50% stenosis; 70 patients in group B received coronary artery angiography Strict rate ≥ 50%. According to the number of coronary lesions, 124 patients with coronary artery stenosis were further divided into 40 cases of single vessel disease group, 38 cases of double-vessel disease group and 46 cases of multi-vessel disease group. All patients underwent carotid ultrasonography to measure the carotid intima-media thickness. Results: The carotid IMT and Gensini scores of group A and group B were significantly higher than those of normal control group, and the carotid intima - media thickness and Gensini score of group B were significantly higher than those of group A , The differences were statistically significant (P <0.05). With the severity of coronary stenosis, carotid intima-media thickness and Gensini score increased gradually. The multi-vessel disease group and double-vessel disease group had significantly higher IMT value and Gensini score than those with single vessel disease group (P <0.05), but there was no significant difference between double-vessel disease group and multi-vessel disease group (P> 0.05) . There was no significant correlation between the thickness of carotid artery IMT and the number of coronary artery lesion and the positive correlation with Gensini score (P <0.01). Conclusion: The intima - media thickness of carotid artery can predict the degree of coronary artery disease better, but it can not predict the extent of coronary artery disease.