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Hann H-WL等于1989年在国际癌症杂志上报道,慢性肝病患者血清铁蛋白含量增高是原发性肝细胞癌(PHC)的一个危险因素.作者在南朝鲜汉城249例患肝病(多数为慢性)的患者进行血清铁蛋白测定观察2～17年,以便验证上述观点.结果发现大多数患者为乙型肝炎病毒(HBV)长期感染者.该组患者在随访的头8个月内未发现有PHC病例,也无死亡病例.其血清铁蛋白水平开始多在300ng/ml以下,8个月内没有升高至300ng/ml以上者.少数患者开始可达300ng/ml以下,但8个月内有所下降至300ng/ml以上.连续多次检测血清铁蛋白量持续增高达300ng/ml以上就容易发生PHC.该项调查还表明,铁蛋白含量男性较女性为高.因此,PHC的发生率男性高
Hann H-WL et al. Reported in the International Journal of Cancer in 1989 that increased serum ferritin levels in patients with chronic liver disease are a risk factor for primary hepatocellular carcinoma (PHC) .According to a study published in International Journal of Cancer, 249 patients with liver disease (mostly chronic ) In patients with ferritin 2 to 17 years of observation in order to verify the above point of view and found that most patients with chronic hepatitis B virus (HBV) infection in the group were not found in the first 8 months of follow-up PHC cases, no deaths, serum ferritin levels began to more than 300ng / ml, within 8 months did not rise to more than 300ng / ml few patients began to reach 300ng / ml or less, but within 8 months Decreased to more than 300ng / ml continuous detection of serum ferritin continued to increase the amount of more than 300ng / ml more prone to PHC.The survey also showed that the content of ferritin in men than women is high.Therefore, the incidence of PHC Male high