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目的探讨环境主要污染物——类雌激素双酚A对女性复发性流产(胚胎停育)的影响。方法收集2014年10月至2016年4月第三军医大学西南医院妇产科门诊不明原因复发性流产或胚胎停育患者80例,选择80例正常妊娠妇女为对照组,使用固相萃取-同位素内标-高效液相色谱质谱联用法检测血清双酚A浓度,按年龄、体质量指数(BMI)、孕周、初潮年龄分组并进行比较,采用单因素和多因素非条件logistic回归模型分析双酚A与复发性流产发生的关联。结果病例组血清双酚A浓度高于对照组[39.51(19.72,57.13)vs 3.56(2.46,6.88)ng/m L,P<0.01];多因素logistic回归分析结果显示:双酚A是复发性流产的危险因素(OR=2.469)。两组间比较,双酚A浓度在年龄≤35岁、BMI、孕周、初潮年龄差异均有统计学意义(P<0.001)。结论双酚A可能与女性复发性流产(胚胎停育)有关。
Objective To investigate the effect of estrogen bisphenol A, a major environmental pollutant, on female recurrent spontaneous abortion (embryo shutdown). Methods Eighty patients with unexplained recurrent spontaneous abortion or outpatient obstetrics at the Southwest Hospital of the Third Military Medical University from October 2014 to April 2016 were selected and 80 normal pregnant women were selected as the control group. Serum bisphenol A concentration was detected by internal standard-high performance liquid chromatography-mass spectrometry (LC-MS / MS), and grouped by age, body mass index (BMI), gestational age and menarche age and compared with univariate and multivariate non-conditional logistic regression models Phenol A is associated with recurrent spontaneous abortion. Results The concentration of serum bisphenol A in the case group was significantly higher than that in the control group [39.51 (19.72,57.13 vs 3.56, 2.46, 6.88 ng / m L, P <0.01]. Multivariate logistic regression analysis showed that bisphenol A was recurrent Risk factors for miscarriage (OR = 2.469). Between the two groups, bisphenol A concentration in the age ≤ 35 years old, BMI, gestational age, menarche age differences were statistically significant (P <0.001). Conclusion Bisphenol A may be related to recurrent spontaneous abortion (embryo suspension) in women.