Aim: To compare 90°, 180°, and 360°selective laser trabeculoplasty (SLT, 532 nm Nd:YAG laser) with latanoprost 0.005%for the control of intraocular pressure (IOP) in ocular hypertension (OHT) and open angle glaucoma (OAG). Methods: A prospective, randomised clinical trial in the Department of Ophthalmology, St Thomas’s Hospital, London, and Clayton Eye Centre, Wakefield, West Yorkshire. 167 patients (167 eyes) with either OHT or OAG were randomised to receive 90°, 180°, and 360°SLT or latanoprost 0.005%at night and were evaluated at 1 hour, 1 day, 1 week and 1,3,6, and 12 months. Results: The mean follow up was 10.3 months (range 1-12 months). Early, transient, complications such as postoperative ocular pain, uveitis, and 1 hour IOP spike occurred in a number of eyes after SLT, with pain being reported more frequently after 360°than 90°treatments (p>0.001). Success rates defined in terms of both a 20%or more and a 30%or more IOP reduction from baseline measurements with no additional antiglaucomatous interventions were better with latanoprost than 90°(p<0.001) and 180°SLT (p<0.02) treatments. Differences in success rates between latanoprost and 360°SLT did not reach statistical significance (p<0.5). Success rates were greater with 180°and 360°compared to 90°SLT (p<0.05). With 360°SLT, 82%of eyes achieved a >20%IOP reduction and 59%a >30%reduction from baseline. Although success rates were better with 360°than 180°SLT treatments, differences did not reach statistical significance. There were no differences with regard to age, sex, race, pretreatment IOP, OHT versus OAG, laser power settings, and total laser energy delivered between eyes which responded, in terms of a >20%and a >30%IOP reduction, and those that did not respond with 180°and 360°SLT treatments. Conclusions: Success rates were higher with latanoprost 0.005%at night than with 90°and 180°SLT treatments. 90°SLT is generally not effective. 360°SLT appears to be an effective treatment with approximately 60%of eyes achieving an IOP reduction of 30%or more. Transient anterior uveitis with associated ocular discomfort is not unusual in the first few days after SLT. Late complications causing ocular morbidity after SLT were not encountered. Aim: To compare 90%, 180 °, and 360 ° selective laser trabeculoplasty (SLT, 532 nm Nd: YAG laser) with latanoprost 0.005% for the control of intraocular pressure (IOP) in ocular hypertension (OHT) and open angle glaucoma OAG). Methods: A prospective, randomized clinical trial in the Department of Ophthalmology, St Thomas’s Hospital, London, and Clayton Eye Center, Wakefield, West Yorkshire. 167 patients (167 eyes) with either OHT or OAG were randomized to receive 90 ° , 180 °, and 360 ° SLT or latanoprost 0.005% at night and were evaluated at 1 hour, 1 day, 1 week and 1, 3, 6, and 12 months. Results: The mean follow up was 10.3 months Early, transient, complications such as postoperative ocular pain, uveitis, and 1 hour IOP spike occurred in a number of eyes after SLT, with pain being reported more frequently after 360 ° than 90 ° treatments (p> 0.001). Success rates defined in terms of both a 20% or more and a 30% or more IOP reduction from baseline measurements with no ad ditional antiglaucomatous interventions were better with latanoprost than 90 ° (p <0.001) and 180 ° SLT (p <0.02) treatments. Differences in success rates between latanoprost and 360 ° SLT did not reach statistical significance (p <0.5). Success rates were greater with 180 ° and 360 ° compared to 90 ° SLT (p <0.05). With 360 ° SLT, 82% of the eyes achieved a> 20% IOP reduction and 59% a> 30% reduction from baseline. Although success rates were better with 360 ° than 180 ° SLT treatments, differences did not reach statistical significance. There were no differences with regard to age, sex, race, pretreatment IOP, OHT versus OAG, laser power settings, and total laser energy delivered between eyes which responded, in terms of a> 20% and a> 30% IOP reduction, and those that did not respond with 180 ° and 360 ° SLT treatments. Conclusions: Success rates were higher with latanoprost 0.005% at night than with 90 ° and 180 ° SLT treatments. 90 ° SLT is generally not effective. 360 ° SLT appears to be an effective treatment with approximately 60% ofeyes achieving an IOP reduction of 30% or more. Transient anterior uveitis with associated ocular discomfort is not unusual in the first few days after SLT. Late complications causing ocular morbidity after SLT were not encountered.