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目的探讨雌、孕激素联合克罗米芬、二甲双胍治疗多囊卵巢综合征(PCOS)合并不孕的临床疗效。方法将2014年12月-2016年9月被青海大学附属医院妇科门诊确诊为PCOS合并不孕患者68例分为研究组(36例)和对照组(32例),研究组采用雌、孕激素+克罗米芬+二甲双胍联合、序贯治疗3个周期;对照组采用克罗米芬+二甲双胍治疗3个周期。结果两组治疗前后,体重指数(BMI)、促黄体生成素(LH)、LH/FSH、雄激素(T)、空腹胰岛素(FINS)、卵巢体积、优势卵泡数有显著性变化,差异有统计学意义(P<0.05),但组间比较差异无统计学意义(P>0.05);两组治疗后围排卵期子宫内膜厚度与妊娠率比较,差异有统计学意义(P<0.05)。结论雌、孕激素联合克罗米芬、二甲双胍治疗多囊卵巢综合征合并不孕妊娠成功率更高,在临床上可以推广。
Objective To investigate the clinical efficacy of estrogen and progesterone combined with clomiphene and metformin in the treatment of polycystic ovary syndrome (PCOS) with infertility. Methods From December 2014 to September 2016, 68 cases diagnosed as PCOS complicated with infertility by gynecology clinic of Affiliated Hospital of Qinghai University were divided into study group (36 cases) and control group (32 cases). The study group was treated with estrogen and progesterone + Clomiphene citrate + metformin, sequential treatment of three cycles; control group with clomiphene citrate treatment metformin three cycles. Results Before and after treatment, the body mass index (BMI), LH, LH / FSH, T and FINS, ovarian volume and predominant follicles changed significantly (P <0.05), but there was no significant difference between the two groups (P> 0.05). There was a significant difference between the two groups in peri-ovulation endometrial thickness and pregnancy rate (P <0.05). Conclusion Estrogen, progesterone combined with clomiphene, metformin in the treatment of polycystic ovary syndrome with infertility pregnancy success rate is higher, it can be popularized in the clinic.