论文部分内容阅读
目的:探讨赖氨匹林对癌性疼痛的治疗效果。方法:选择按WHO“三阶梯”止痛方案需进行第二、第三级药物治疗的患者45例,随机分为A、B、C三组。分别肌注赖氨匹林0.9g、1.8g、哌替啶50mg,观察起效时间、镇痛持续时间及副作用,用视觉模拟标尺评分法(VAS)评定镇痛效果。结果:A、B两组起效时间分别为18.1±6.2分钟和16.3±5.8分钟,慢于C组6.4±2.1分钟(P<0.05),镇痛持续时间分别为316.3±95分钟和418.6±85分钟,长于C组176.3±61.7分钟(P<0.05)两组给药后20和30分钟VAS评分无显著差异(P>0.05)。结论:赖氨匹林能有效地应用于癌痛病人第二、三级止痛,具有持续时间长、效果显著、副作用少的优点。
Objective: To investigate the effect of lysine hydrochloride on cancer pain. Methods: A total of 45 patients who required second- and third-level drug treatment according to WHO’s “Three Steps” analgesia plan were randomly divided into A, B, and C groups. Intramuscular injection of lysine hydrochloride 0.9g, 1.8g, pethidine 50mg, observed onset time, duration of analgesia and side effects, visual analogue scale score (VAS) assessment of analgesic effect. Results: The onset time of group A and B were 18.1±6.2 minutes and 16.3±5.8 minutes respectively, which was slower than that of group C (6.4±2.1 minutes) (P<0.05). The duration of analgesia was 316.3±95 minutes and 418.6±85 respectively. Minutes, longer than the C group 176.3 ± 61.7 minutes (P <0.05) VAS scores at 20 and 30 minutes after administration of the two groups were not significantly different (P> 0.05). Conclusion: Lysine is effective in the second and third stage pain relief in patients with cancer pain. It has the advantages of long duration, significant effect, and fewer side effects.