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目的观察枸橼酸莫沙必利与四磨汤联合治疗老年糖尿病性胃轻瘫的临床疗效。方法将84例老年糖尿病胃轻瘫患者随机分为两组,均给予常规降糖治疗,对照组加用枸橼酸莫沙必利,治疗组在对照组基础上加用四磨汤口服液治疗。连续治疗6周,对比两组患者血糖控制情况、胃排空时间、有效率、不良反应发生率以及半年内复发率。结果治疗组有效率显著高于对照组(P<0.01);两组治疗前空腹血糖(FPG)、餐后2h血糖(2h PG)及胰岛素抵抗指数(IRI)比较无显著差异(P>0.05),治疗后均较治疗前显著改善(P<0.05);两组治疗前胃排空时间比较无统计学差异(P>0.05),治疗后两组胃排空时间均显著缩短(P<0.01),且治疗后治疗组胃排空时间显著短于对照组(P<0.01);两组不良反应发生率比较无统计学差异(P>0.05);治疗组半年内复发率为4.8%,显著低于对照组的28.6%(P<0.01)。结论枸橼酸莫沙必利联合四磨汤用于老年糖尿病胃轻瘫患者的治疗,可有效改善患者的症状,促进胃肠蠕动能力,缩短胃排空时间,改善胃肠道内分泌,提高胃肠道消化功能,且复发率较低,安全可靠,值得推广。
Objective To observe the clinical efficacy of mosapride citrate combined with Sihuang decoction in the treatment of senile diabetic gastroparesis. Methods Eighty-four elderly patients with diabetic gastroparesis were randomly divided into two groups, all given conventional hypoglycemic therapy, the control group plus mosapride citrate, the treatment group on the basis of the control group plus Si Mogan oral liquid treatment . Continuous treatment for 6 weeks, compared two groups of patients with glycemic control, gastric emptying time, effective rate, the incidence of adverse reactions and recurrence within six months. Results The effective rate of the treatment group was significantly higher than that of the control group (P <0.01). There was no significant difference in fasting blood glucose (FPG), 2h PG and IRI between the two groups before treatment (P> 0.05) (P0.05) .There was no significant difference in gastric emptying time between the two groups before treatment (P0.05), and the gastric emptying time of both groups was significantly shorter after treatment (P0.01) , And the time of gastric emptying in the treatment group was significantly shorter than that in the control group (P <0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). The recurrence rate in the treatment group within 6 months was significantly lower 28.6% of the control group (P <0.01). Conclusion Mosapride citrate combined with Soshitang for the treatment of elderly diabetic gastroparesis patients can effectively improve the symptoms of patients, promote gastrointestinal motility, shorten the time of gastric emptying, improve gastrointestinal endocrine, improve the stomach Intestinal digestive function, and the recurrence rate is low, safe and reliable, it is worth promoting.