多囊卵巢综合征(PCOS)是一种育龄妇女的内分泌失调疾病,其发病原因未完全明了。临床上将循环中脱氢表雄酮(DHEA)的代谢产物——硫酸脱氢表雄酮(DHEAS)的含量用作检测肾上腺皮质分泌物的标记。20%～60%的PCOS患者表现高水平DHEAS,且具有家庭聚集性。此研究旨在评价PCOS患者及其姐妹的临床特征和基础血清DHEAS水平。 Polycystic ovary syndrome (PCOS) is a woman of childbearing age endocrine disorders, the cause of the disease is not fully understood. Clinically, the metabolite of dehydroepiandrosterone (DHEA) circulating, DHEA, is used as a marker for detecting adrenocortical secretions. 20% to 60% of PCOS patients exhibit high levels of DHEAS and have family aggregation. The aim of this study was to evaluate the clinical features and basal serum DHEAS levels in PCOS patients and their sisters.