我国糖尿病患者目前已超过1亿人,给社会发展带来严重负担。糖尿病的重要特征是高血糖,长期高血糖可导致血管病变、神经病变等一系列慢性并发症,是糖尿病患者致残、致死的主要原因。高血糖能够通过引起血管内皮细胞功能损伤等多种病理生理机制,导致糖尿病血管病变等多种并发症[1]。硫化氢(H2S)作为一种新型的内源性气体信号分子,是近年来研究的热点。生理浓度下的硫化氢对多种细胞起到保护作用,目 Diabetic patients in our country have now exceeded 100 million people, posing a heavy burden on social development. Diabetes is an important feature of high blood sugar, long-term high blood sugar can lead to vascular disease, neuropathy and a series of chronic complications, is the main cause of disability and death of diabetic patients. Hyperglycemia can cause a variety of pathophysiological mechanisms such as vascular endothelial dysfunction and other pathophysiological mechanisms, leading to complications such as diabetic vascular disease [1]. Hydrogen sulfide (H2S), as a new type of endogenous gas signaling molecule, has been a hot spot in recent years. Hydrogen sulfide at physiological concentrations of a variety of cells to play a protective role