论文部分内容阅读
目的 :探讨含奥美拉唑的短程三联疗法对Hp阳性的十二指肠溃疡的疗效 ,以及对十二指肠溃疡复发的影响。方法 :12 8例Hp阳性的十二指肠溃疡病人随机分成三组 ,A组口服奥美拉唑 (洛赛克 ) 2 0mg每日 2次 ,克拉霉素 2 5 0mg每日 2次 ,甲硝唑 40 0mg每日 2次 ,疗程为 1周 ;B组用药同A组 ,疗程为两周 ,C组在A组的用药基础上加用铋剂 (德诺 )2 40mg每日两次 ,疗程为 1周。于停药后 1月以及 12月后复查胃镜。结果 :A组患者Hp根除率为 91.11% ,B组 95 .12 % ,C组为 92 .86 % ,A组与B组、A组与C组比较 ,经统计学处理 ,P值均 >0 .0 5 ,故差异无显著性 ;三组患者溃疡愈合率分别为75 .5 6 %、82 .93 %和 80 .95 % ,经统计学处理 ,P >0 .0 5 ,故差异亦无显著性。三组患者 1年后溃疡复发率分别为 5 .88%、2 .94%及 2 .86 % ,P >0 .0 5 ,无显著性差异。结论 :以洛赛克为核心的三联 1周疗法 ,具有疗程短 ,疗效高 ,副作用少等优点 ,是当前较为理想的根除Hp治疗方案。Hp根除可有效地防止溃疡病的发生与复发。
Objective: To investigate the curative effect of short-course triple therapy with omeprazole on Hp-positive duodenal ulcer and its effect on the recurrence of duodenal ulcer. Methods: A total of 12 8 patients with Hp-positive duodenal ulcer were randomly divided into three groups. Group A received omeprazole (Losec) 20 mg twice daily and clarithromycin 250 mg twice daily Nidazole 40 0mg twice daily for 1 week; B group with the same treatment A group, treatment for two weeks, C group in the A group based on the use of bismuth (De Novo) 2 40mg twice daily, Treatment for 1 week. Endoscopy in January and December after review of gastroscopy. Results: The Hp eradication rate was 91.11% in group A, 95.12% in group B and 92.86% in group C, and the values of P in group A and group B were statistically higher than those in group C .0 5, so the difference was not significant; three groups of patients with ulcer healing rates were 75.56%, 82.93% and 80.95%, the statistical analysis, P> 0.05, so the difference is no Significance. The recurrence rates of ulcer in three groups of patients after one year were respectively 5.88%, 2.94% and 2.86%, P> 0.05, no significant difference. Conclusion: Losec as the core of the triple therapy for one week, with short course, high efficacy, fewer side effects, is currently the ideal treatment of eradication Hp. Hp eradication can effectively prevent the occurrence and recurrence of ulcer disease.