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目的:探讨小儿癫痫的诊断和临床治疗体会。方法:选取我院2010年7月~2012年7月收治的小儿癫痫患者42例,按癫痫的类型选择不同用药。结果:(1)7例完全控制,20例显效,10例有效,5例效差,无无效患儿。(2)卡马西平和丙戊酸钠血药浓度均存在一定差异,显效率未随浓度的增加而增大。(3)定期复查单一使用丙戊酸钠进行治疗的癫痫患儿肝功能,未发现肝功能损害。对于联合应用多种抗癫痛药物进行治疗的癫痫患儿复查肝功能2例出现肝功能异常,在经过停药处理以及护肝的相关治疗后,均恢复正常。对本组42例患者随访1年,均无癫痫再发作。结论:对小儿癫痫做出明确诊断,并根据临床表现和脑电图明确发作类型,查找病因,对癫痫的不同发作类型采用合适的药物进行治疗,单一用药或者联合用药的同时需注意药物的毒副作用,检查肝功能,一旦发现肝功受损需立即停药,同时进行护肝治疗,癫痫治疗后需定期随访,以防复发。
Objective: To explore the diagnosis and clinical experience of pediatric epilepsy. Methods: Forty-two children with epilepsy in our hospital from July 2010 to July 2012 were selected according to the type of epilepsy. Results: (1) 7 cases were completely controlled, 20 cases markedly effective, 10 cases effective, 5 cases ineffective, no ineffective children. (2) Both plasma levels of carbamazepine and valproic acid have some differences, the effective rate did not increase with the increase of concentration. (3) regular review of a single use of sodium valproate for treatment of liver function in children with epilepsy, no liver damage was found. For the combination of multiple anti-epilepsy drugs for treatment of children with recurrent liver function in two cases of liver dysfunction, after treatment and protection of liver related to treatment, were back to normal. 42 patients in this group were followed up for 1 year, no recurrent seizures. Conclusion: The diagnosis of pediatric epilepsy made clear, and based on clinical manifestations and EEG clearly the type of attack, find the cause of the epilepsy seizures of different types of drugs using appropriate treatment, single or combination of drugs should pay attention to drug toxicity Side effects, check the liver function, once found liver damage need immediate withdrawal, while liver protection treatment, epilepsy treatment should be followed up regularly to prevent recurrence.