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用放射免疫测定法（ＲＩＡ）对生活在海拔２２６１ｍ地区（西宁）和海拔３ｍ地区（青岛）的成年Ｗｉｓｔａｒ大鼠脑内β－内啡肽免疫活性物质（β－ＥＰ）的含量进行了比较研究。结果表明垂体内β－ＥＰ的含量与平原者对照组相比，下降非常显著（Ｐ＜０．０１）；皮层与平原者对照组相比，下降亦有显著性意义（Ｐ＜０．０５）。丘脑桥延、纹状体内β－ＥＰ的含量有所下降，但无统计学意义（Ｐ＞０．０５）。提示，高原环境对大鼠各脑区β－ＥＰ的含量有不同程度的影响。
The contents of β-endorphin immunoreactive substance (β-EP) in brain of adult Wistar rats living in 2261m above sea level (Xining) and 3m above sea level (Qingdao) were compared by radioimmunoassay (RIA) . The results showed that the content of β-EP in the pituitary was significantly lower than that in the control group (P <0.01), and there was also a significant decrease in the cortex compared with the control group (P <0.05) . Thalamic extension, the content of β-EP in striatum decreased, but not statistically significant (P> 0.05). Prompted that the plateau environment on rat brain β-EP content varying degrees.