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目的 研究肝血管平滑肌脂肪瘤 (HAML)的临床病理特点。方法 收集临床相关资料 ,采用常规HE切片、特殊染色、免疫组化、电镜等方法对本院 8例及会诊 3例HAML进行研究。结果 11例HAML病人影像学及症状、体征均有其特征 ,病理形态学上均显示有血管周上皮样细胞 ,血管分厚壁及薄壁两种 ,上皮样细胞分为 4种形态 ,形态与免疫表型有一定相关关系 ,PAS部分上皮样细胞胞浆阳性且抗淀粉酶消化 ,电镜下可见类似前黑色素小体的特殊晶体样结构及密体。结论 HAML是一种好发于中青年女性的良性肿瘤 ,肌动蛋白、HMB4 5阳性为HAML的特点 ,HAML因其特殊的光镜及电镜下形态、免疫组化特点及其临床特征而归入血管周上皮样细胞相关肿瘤。
Objective To study the clinicopathological features of hepatic angiomyolipoma (HAML). Methods The clinical data were collected and routinely performed HE staining, special staining, immunohistochemistry, electron microscopy and other methods. Eight hospitalized patients and 3 hospitalized patients with HAML were studied. Results The imaging features, symptoms and signs of 11 patients with HAML were characterized by perivascular epithelioid cells, which were divided into two types: vascular wall thickness and thin wall. The epithelioid cells were divided into 4 types of morphology, morphology and immunity. There is a certain correlation between phenotypes. Part of the PAS epithelial cells are cytoplasmic and anti-amylase-digestible. Under electron microscopy, special crystal-like structures and dense bodies resembling premesopores are observed. Conclusions HAML is a benign tumor that occurs in young and middle-aged women. Actin and HMB4 5 are characteristic of HAML. HAML is attributed to its special morphology and immunohistochemistry and clinical features under light and electron microscope. Perivascular epithelioid cell-associated tumors.