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目的:研究化脓性链球菌的药物敏感试验谱,以指导临床合理使用抗菌药。方法:对自2013年1月至2014年10月在广东省连州卫生学校附属医院(连州市红十字会医院)住院和门诊患者的标本分离到的207株化脓性链球菌进行20种抗菌药的药物敏感试验,统计、分析药物敏感试验谱。结果:敏感率最高的前3位万古霉素、亚胺培南、头孢硫咪都大于80%,而耐药率最高的前3位红霉素、阿奇霉素、青霉素都大于82%,红霉素、阿奇霉素、青霉素、苯唑西林、氧氟沙星、哌啦西林和头孢他定7种抗菌药的耐药率超过30%。结论:化脓性链球菌对连州市红十字会医院(以下简称“医院”)临床常用的20种抗菌药的耐药谱较广。该细菌感染首选的抗菌药为万古霉素、亚胺培南和头孢硫咪,红霉素、阿奇霉素、青霉素、苯唑西林、氧氟沙星、哌啦西林和头孢他定已不再适合于临床治疗的一线药物。
Objective: To study the drug susceptibility test spectrum of Streptococcus pyogenes to guide clinical use of antibacterials. Methods: 207 strains of Streptococcus pyogenes isolated from specimens of inpatients and outpatients from January 2013 to October 2014 in Lianzhou Health School Affiliated Hospital of Guangdong Province (Lianzhou Red Cross Hospital) were subjected to 20 kinds of antibacterial Drug susceptibility testing of drugs, statistics, analysis of drug sensitivity test spectrum. Results: The top 3 strains of vancomycin, imipenem and cefaperazole with the highest sensitivity rates were more than 80%, while the top 3 erythromycin, azithromycin and penicillin with the highest drug resistance rate were all over 82% , Azithromycin, Penicillin, Oxacillin, Ofloxacin, Piperacillin and Ceftazidime were more than 30%. Conclusion: Streptococcus pyogenes has a broad spectrum of resistance to 20 commonly used antibiotics in Lianzhou Red Cross Hospital (hereinafter referred to as “Hospital”). The antibacterials of choice for this bacterial infection are vancomycin, imipenem and cefapethrin, erythromycin, azithromycin, penicillin, oxacillin, ofloxacin, penzilin and ceftazidime are no longer suitable First-line treatment of clinical medicine.