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目的观察血管紧张素Ⅱ受体拮抗剂对急性心肌梗死后左室重构的影响 ,间接判断其对左室重构的抑制作用。方法以初次急性心肌梗死入院者为研究对象 ,观察组给氯沙坦 ,对照组用美托洛尔 ,观察入院之初及 3个月后用二维超声测量的左室重量。结果观察组平均心肌重量低于对照组 (P <0 .0 5)。结论血管紧张素Ⅱ受体拮抗剂能有效地控制急性心肌梗死后左室重构
Objective To investigate the effect of angiotensin Ⅱ receptor antagonist on left ventricular remodeling after acute myocardial infarction and indirectly determine its inhibitory effect on left ventricular remodeling. Methods The patients admitted to the hospital for the first time with acute myocardial infarction were enrolled in the study. Losartan was given to the observation group and metoprolol was given to the control group. The left ventricular mass was measured by two-dimensional ultrasound at the beginning of admission and 3 months later. Results The average myocardial weight of the observation group was lower than that of the control group (P <0.05). Conclusion Angiotensin Ⅱ receptor antagonist can effectively control left ventricular remodeling after acute myocardial infarction