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目的探讨TNF-α、Caspase-3在子痫前期患者胎盘组织中的表达及意义。方法子痫前期患者60例(包括子痫前期轻度、子痫前期重度各30例)为实验组,正常妊娠妇女30例为对照组,利用免疫组织化学SP法检测两组胎盘组织中TNF-α、Caspase-3的表达。结果实验组TNF-α的表达均较对照组明显升高(P<0.05),且随着子痫前期的病情加重,TNF-α的表达逐渐增加。实验组Caspase-3的表达均较对照组明显升高(P<0.05),且随着子痫前期病情的加重,Caspase-3的表达逐渐增加。结论 TNF-α、Caspase-3在患者胎盘组织中随病情的加重逐渐升高的表达,有助于预测子痫前期的发生发展。
Objective To investigate the expression and significance of TNF-α and Caspase-3 in placenta of preeclampsia patients. Methods 60 cases of preeclampsia (including mild preeclampsia and 30 severe preeclampsia) were selected as experimental group and 30 normal pregnant women as control group. Immunohistochemical SP method was used to detect the expression of TNF- α, Caspase-3 expression. Results The expression of TNF-α in experimental group was significantly higher than that in control group (P <0.05), and the expression of TNF-α gradually increased with the aggravation of preeclampsia. The expression of Caspase-3 in the experimental group was significantly higher than that in the control group (P <0.05), and the expression of Caspase-3 gradually increased with the aggravation of preeclampsia. Conclusions The expression of TNF-α and Caspase-3 in the placenta of patients with the progressive increase of the disease may help to predict the occurrence and development of preeclampsia.