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目的 :观察调肝泻火汤对胰岛素抵抗 (IR)大鼠肿瘤坏死因子 -α(TNF-α)等相关指标的影响 ,探讨该方预防 IR的作用机制。方法 :将动物随机分为模型组、中药组和正常组 ,以高脂饮食复制 IR大鼠模型 ,中药组予高脂饮食的同时予中药灌胃 ,正常组给予基础饲料喂养 ,共观察 8周 ,评价模型及该方对 IR的影响。结果 :调肝泻火汤升高胰岛素敏感性指数 ,改善糖耐量 ,降低空腹血胰岛素、TNF-α水平 (与模型组比较 P <0 .0 1,P <0 .0 5 )。结论 :调肝泻火汤能有效预防高脂饮食所致大鼠 IR,其机制可能是通过受体后环节 ,调控 TNF-α而起作用
Objective : To observe the effect of Tiaoganxiehuo decoction on the related indexes of tumor necrosis factor-α (TNF-α) in rats with insulin resistance (IR), and to explore the mechanism of action of this prescription in preventing IR. METHODS: Animals were randomly divided into model group, traditional Chinese medicine group and normal group. IR rat model was duplicated with high-fat diet. Chinese medicine group was given intragastric administration with high-fat diet, while normal group was given basal diet for 8 weeks. , Evaluate the model and the impact of this party on IR. Results: Tiaoganxiehuo decoction increased insulin sensitivity index, improved glucose tolerance, decreased fasting insulin, TNF-α levels (P <0.01, P <0.05). Conclusion: Tiaoganxiehuo decoction can effectively prevent IR induced by high-fat diet in rats, and the mechanism may be through regulating the TNF-α through the post-receptor