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目的 探究药物治疗及心理治疗应用于42例阿尔茨海默病患者中的临床治疗效果.方法 以简单随机抽样法纳入42例阿尔茨海默病患者作为研究对象,病例选取时间为2019年1月～2020年12月.以随机数字表法将其分为参照组和治疗组,每组21例,两组患者均接受同一药物治疗方案(盐酸多奈哌齐+奥氮平),治疗组在此基础上给予心理治疗,以统计学对两组治疗前后心理状态、精神状态、日常生活能力、家庭功能、生命质量以及用药依从性进行处理分析.结果 治疗前,两组患者焦虑自评量表(SAS)评分以及焦虑阳性症状率、抑郁自评量表(SDS)评分以及抑郁阳性症状率相似(P＞0.05),治疗后,治疗组SAS评分及焦虑阳性症状率、SDS评分及抑郁阳性症状率均明显低于参照组(P＜0.05);治疗前,两组患者简易智力状态检查量表(MMSE)、日常生活活动能力(ADL)、家庭功能评定(FAD)评分无明显差异(P＞0.05),治疗后,治疗组MMSE、ADL、FAD评分均明显优于参照组(P＜0.05);治疗前,两组患者症状控制、功能障碍以及总体健康等生命质量指标评分相似(P＞0.05),治疗后,治疗组生命质量各项指标评分明显高于参照组(P＜0.05);治疗组用药依从性85.71％明显高于参照组的42.86％(P＜0.05).结论 药物治疗及心理治疗应用于老年痴呆患者护理中能明显缓解负面情绪,改善其精神状态、生活能力以及家庭功能,对生命质量产生积极影响,建议优先选择.“,”Objective To explore the clinical therapeutic effects of drug therapy and psychotherapy in 42 patients with Alzheimer\'\'s disease. Methods A simple random sampling method was used to enroll 42 patients with Alzheimer\'\'s disease as the research objects, and the cases were selected from January 2019 to December 2020. The reference group and the treatment group were divided into the reference group and the treatment group by a random number table, each with 21 cases. Both groups of patients received the same drug treatment plan (donepezil hydrochloride + olanzapine). The treatment group was given psychotherapy on this basis. The mental state, mental state, ability of daily living, family function, quality of life, and medication compliance of the two groups before and after treatment were processed and analyzed. Results Before treatment, the two groups of patients had similar scores on the self-rating anxiety scale (SAS) and the rate of anxiety positive symptoms, self-rating depression scale (SDS) scores, and the rate of positive depression symptoms (P＞0.05), after treatment, the SAS scores of the treatment group were similar. The rate of positive symptoms of anxiety, SDS score, and positive symptoms of depression were significantly lower than the reference group (P＜0.05); before treatment, the two groups of patients\'\' mini-mental state examination (MMSE), activities of daily living (ADL), family there was no significant difference in family assessment device (FAD) scores (P＞0.05), after treatment, the MMSE, ADL, and FAD scores of the treatment group were significantly better than those of the reference group(P＜0.05); before treatment, the two groups of patients had symptoms control, dysfunction and overall health and other quality of life index scores were similar (P＞0.05), after treatment, the scores of quality of life indicators in the treatment group were significantly higher than those of the reference group (P＜0.05); the medication compliance of the treatment group was 85.71％ significantly higher than that of the reference group 42.86％ (P＜0.05). Conclusion The application of medication and psychotherapy in the nursing of senile dementia patients can significantly relieve negative emotions, improve their mental state, living ability, and family functions, and have a positive impact on the quality of life. It is recommended to choose first.