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目的探讨苦参素联合干扰素对HBeAg阳性慢性乙型肝炎(CHB)的临床疗效。方法随机选取我院住院的HBeAg抗原阳性CHB患者96例分成2组,治疗组用干扰素α-2b再联合应用苦参素注射液及苦参素胶囊,总疗程均为6个月。对照组单用干扰素α-2b治疗,疗程及剂量同治疗组。结果治疗后3个月、6个月及疗程结束半年后随访,治疗组的HBV-DNA、HBeAg阴转率均优于对照组(P<0.05)。结论对HBeAg阳性CHB患者,用干扰素α-2b联合苦参素治疗较单用干扰素效果为佳。
Objective To investigate the clinical effect of oxymatrine combined with interferon on HBeAg-positive chronic hepatitis B (CHB). Methods Ninety-six patients with HBeAg-positive CHB hospitalized in our hospital were randomly divided into two groups. The treatment group was treated with interferon α-2b combined with oxymatrine injection and oxymatrine capsules for a total of six months. Control group with interferon α-2b treatment, treatment and dose with the treatment group. Results After three months, six months and six months after the end of treatment, the negative conversion rates of HBV-DNA and HBeAg in the treatment group were better than those in the control group (P <0.05). Conclusion HBeAg-positive patients with CHB, with interferon α-2b combined with oxymatrine than interferon alone better.