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合成甾体 RU486具有强抗孕激素和抗糖皮质激素的特性,临床上已广泛用作中止妊娠、治疗柯兴氏综合征和每月一次的避孕药物。作者研究了正常妇女中 RU486的药代动力学和其对垂体前叶激素分泌的影响。研究包括15例妇女,其中口服 RU486组6例,年龄21～33岁(平均26.2岁),月经周期规则(平均28.3天,范围26～30天),对照组9例,年龄20～42岁,月经周期规则(平均28天,范围26～32天)。15例妇女体重均在标准体重±10%以内。RU486组妇女均在滤泡早期(周期第1～5天)开始研究,禁食一夜后于早晨8时,于前臂静脉插管取血,服药前取2次血作为基础资料,然后口服 RU486 4 mg/kg,头2小时每30分
Synthetic steroid RU486 has strong anti-progesterone and anti-glucocorticoid properties, has been widely used clinically as termination of pregnancy, treatment of Cushing’s syndrome and once-monthly contraceptives. The authors studied the pharmacokinetics of RU486 and its effect on the secretion of anterior pituitary hormones in normal women. The study included 15 women of whom 6 were oral RU486, aged 21-33 years (mean, 26.2 years), with regular menstrual cycles (mean 28.3 days, range, 26-30 days) and 9 in the control group, aged 20-42 years, Menstrual cycle rules (an average of 28 days, the range of 26 to 32 days). The weight of 15 women was within ± 10% of the standard weight. RU486 women in the early follicles (cycle 1 to 5 days) to start the study, fasted overnight at 8:00 in the forearm venous catheter blood taken two times before taking the blood as the basis for data, and then oral RU486 4 mg / kg, the first two hours every 30 minutes