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目的：研究白细胞介素６（ＩＬ６）在２，４二硝基氟苯（ＤＮＦＢ）诱导的ＩＶ型变态反应中的表达及不同剂量的白藜芦醇对ＤＮＦＢ诱导的ＩＶ型变态反应中ＩＬ６生成的量效关系，探讨ＩＬ６在免疫性炎症中的作用及白藜芦醇抗炎作用机理。方法：采用免疫组织化学的方法。结果：白藜芦醇皮下给药５０ｍｇ·ｋｇ－１可明显抑制由ＤＮＦＢ诱导的ＩＶ型变态反应中的小鼠耳肿胀，抑制率为７０％。白藜芦醇在皮下给药５０，１００ｍｇ·ｋｇ－１剂量下，可抑制ＤＮＦＢ诱导的ＩＶ型变态反应中ＩＬ６的生成。结论：ＤＮＦＢ诱导的ＩＶ型变态反应确有ＩＬ６的表达，且白藜芦醇抗炎作用可能与抑制ＩＬ６生成有关
Objective: To investigate the expression of interleukin-6 (IL-6) in type IV allergy induced by 2,4 dinitrofluorobenzene (DNFB) and the effect of different doses of resveratrol on DNFB-induced type IV allergy IL-6 in the dose-effect relationship, to explore the IL 6 in the role of immune inflammation and resveratrol anti-inflammatory mechanism. Methods: Immunohistochemical methods were used. Results: Subcutaneous administration of resveratrol at 50 mg · kg-1 significantly inhibited ear swelling in mice induced by DNFB and the inhibition rate was 70%. Resveratrol subcutaneously administered 50,100mg · kg-1 dose, can inhibit DNFB-induced type IV allergy in IL 6 generation. Conclusion: DNFB-induced type IV allergy does have IL 6 expression, and the anti-inflammatory effect of resveratrol may be related to the inhibition of IL 6 production